An emerging hypothesis for a cause of Agitation in Alzheimer’s Dementia (AAD)
Dysfunction in norepinephrine, serotonin, and dopamine (NSD) neurotransmitter systems may result in agitated behaviors in AAD.1,2
How might modulating these 3 neurotransmitter systems help restore balance in AAD?
Imbalance of top-down executive function and bottom-up emotional drive in AAD1-3
Dysfunction of NSD neurotransmitter systems in AAD1-3
Hypothetical Neurotransmitter Systems Activity in AAD
system
hyperactivity4-8
system
deficits9-11
system
dysregulation9,12-15
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